You can program the nRF52840 chip directly to take full advantage of the Cortex-M4 processor, and then calling into the Nordic SoftDevice radio stack when you need to communicate over BLE. Since the underlying API and peripherals are the same for the '832 and '840, you can supercharge your older nRF52832 projects with the same exact code, with a single recompile!
CircuitPython works best with disk drive access, and this is the only BLE-plus-USB-native chip that has the memory to handle running a little Python interpreter. The massive RAM and speedy Cortex M4F chip make this a good match.
Plenty of GPIO, analog inputs, PWM, timers, etc. Best of all, it's got that native USB! Finally, no need for a separate USB serial chip like CP2104 or FT232. Serial is handled as a USB CDC descriptor, and the chip can act like a keyboard, mouse, MIDI device, or even disk drive. This chip has TinyUSB support – that means you can use it with Arduino as a native USB device and act as UART (CDC), HID, Mass Storage, MIDI, and more!